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Studies on arylfuran derivatives. Part XI. Synthesis, characterisation and biological studies on some Mannich bases carrying 2,4-dichlorophenylfurfural moiety.

Authors
  • Holla, B S
  • Rao, B S
  • Shridhara, K
  • Akberali, P M
Type
Published Article
Journal
Il Farmaco
Publisher
Elsevier
Publication Date
May 01, 2000
Volume
55
Issue
5
Pages
338–344
Identifiers
PMID: 10983278
Source
Medline
License
Unknown

Abstract

A series of 3-substituted-4-[5-(2,4-dichlorophenyl)-2-furfurylidine]amino-5-me rcapto-1, 2,4-triazoles (3) are synthesised. Aminomethylation of 3 with formaldehyde and a primary/secondary amine furnished Mannich bases 4 and 5. Both Schiff bases 3 and Mannich bases 4 and 5 are characterised on the basis of IR, 1H NMR, mass spectral data and elemental analysis. All the newly synthesised compounds are tested for their antibacterial activities. Some of the selected compounds are also tested for their fungicidal and herbicidal properties.

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