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Structures of prokaryotic ribosomal proteins: implications for RNA binding and evolution.

Authors
  • Ramakrishnan, V
  • Davies, C
  • Gerchman, S E
  • Golden, B L
  • Hoffmann, D W
  • Jaishree, T N
  • Kyila, J H
  • Porter, S
  • White, S W
Type
Published Article
Journal
Biochemistry and cell biology = Biochimie et biologie cellulaire
Publication Date
Jan 01, 1995
Volume
73
Issue
11-12
Pages
979–986
Identifiers
PMID: 8722013
Source
Medline
License
Unknown

Abstract

After a long hiatus, the pace of determination of the structures of ribosomal proteins has accelerated dramatically. We discuss here the structures of five ribosomal proteins from Bacillus stearothermophilus: S5, S17, L6, L9, and L14. These structures represent several new motifs. Each of these structures has revealed new insights, and we have developed criteria for recognizing RNA-binding regions of each protein and correlating the structures with such properties as antibiotic resistance. The information here should also prove invaluable in an eventual high-resolution picture of the intact ribosome.

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