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Structures and biological activities of three synaptic antagonists from orb weaver spider venom.

Authors
  • Adams, M E
  • Carney, R L
  • Enderlin, F E
  • Fu, E T
  • Jarema, M A
  • Li, J P
  • Miller, C A
  • Schooley, D A
  • Shapiro, M J
  • Venema, V J
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Oct 29, 1987
Volume
148
Issue
2
Pages
678–683
Identifiers
PMID: 3689366
Source
Medline
License
Unknown

Abstract

The venom of Argiope aurantia, an orb weaver spider, contains a mixture of low molecular weight "argiotoxins", which block neuromuscular transmission in insects. Complete structure elucidation of three argiotoxins reveals common features; a hydrophilic, basic domain of arginine, a polyamine and asparagine is connected to an aromatic moiety contributed either by 4-hydroxyindole-3-acetic acid or 2,4-dihydroxyphenylacetic acid. Structural assignments of two argiotoxins are verified by chemical synthesis. The argiotoxins cause reversible paralysis when injected into insects and this is correlated with a stimulus-dependent inhibition of skeletal neuromuscular transmission at submicromolar concentrations.

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