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Structure of the thioredoxin-fold domain of human phosducin-like protein 2.

Authors
  • Lou, Xiaochu
  • Bao, Rui
  • Zhou, Cong Zhao
  • Chen, Yuxing
Type
Published Article
Journal
Acta Crystallographica Section F Structural Biology and Crystallization Communications
Publisher
International Union of Crystallography
Publication Date
Feb 01, 2009
Volume
65
Issue
Pt 2
Pages
67–70
Identifiers
DOI: 10.1107/S1744309108037342
PMID: 19193988
Source
Medline
License
Unknown

Abstract

Human phosducin-like protein 2 (hPDCL2) has been identified as belonging to subgroup II of the phosducin (Pdc) family. The members of this family share an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. The X-ray crystal structure of the Trx-fold domain of hPDCL2 was solved at 2.70 A resolution and resembled the Trx-fold domain of rat phosducin. Comparative structural analysis revealed the structural basis of their putative functional divergence.

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