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Structure, Function, and Regulation of the Junctophilin Family

Authors
  • Hall, Duane D.
  • Takeshima, Hiroshi
  • Song, Long-Sheng
Type
Published Article
Journal
Annual Review of Physiology
Publisher
Annual Reviews
Publication Date
Feb 12, 2024
Volume
86
Pages
123–147
Identifiers
DOI: 10.1146/annurev-physiol-042022-014926
Source
Annual Reviews
Keywords
License
Green

Abstract

In both excitable and nonexcitable cells, diverse physiological processes are linked to different calcium microdomains within nanoscale junctions that form between the plasma membrane and endo-sarcoplasmic reticula. It is now appreciated that the junctophilin protein family is responsible for establishing, maintaining, and modulating the structure and function of these junctions. We review foundational findings from more than two decades of research that have uncovered how junctophilin-organized ultrastructural domains regulate evolutionarily conserved biological processes. We discuss what is known about the junctophilin family of proteins. Our goal is to summarize the current knowledge of junctophilin domain structure, function, and regulation and to highlight emerging avenues of research that help our understanding of the transcriptional, translational, and post-translational regulation of this gene family and its roles in health and during disease.

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