Affordable Access

Structure and function of the Epstein-Barr virus BZLF1 protein.

Authors
  • Packham, G
  • Economou, A
  • Rooney, C M
  • Rowe, D T
  • Farrell, P J
Type
Published Article
Journal
Journal of virology
Publication Date
May 01, 1990
Volume
64
Issue
5
Pages
2110–2116
Identifiers
PMID: 2157874
Source
Medline
License
Unknown

Abstract

Five DNA-binding sites for the Epstein-Barr virus BZLF1 protein have been identified within three of the early viral promoters, and four of these binding sites contain a consensus AP-1 site. The part of the BZLF1 protein required for sequence-specific DNA binding to one of these AP-1-like sites was identified by deletion mapping. Site-directed mutagenesis of this DNA target suggests that BZLF1 may work partly by overcoming a cellular repressor of viral transcription.

Report this publication

Statistics

Seen <100 times