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Structure and chromosomal localization of the human thrombospondin gene.

Authors
Type
Published Article
Journal
Genomics
Publication Date
Volume
6
Issue
4
Pages
685–691
Identifiers
PMID: 2341158
Source
Medline

Abstract

Thrombospondin (THBS1) is a large modular glycoprotein component of the extracellular matrix and contains a variety of distinct domains, including three repeating subunits (types I, II, and III) that share homology to an assortment of other proteins. Determination of THBS1 gene structure has revealed that the type I repeat modules are encoded by symmetrical exons and that the heparin-binding domain is encoded by a single exon. To further elucidate the higher level organization of THBS1, the gene was localized to the q11-qter region of chromosome 15.

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