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Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent Brequinar Sodium.

Authors
  • Pitts, W J
  • Jetter, J W
  • Pinto, D J
  • Orwat, M J
  • Batt, D G
  • Sherk, S R
  • Petraitis, J J
  • Jacobson, I C
  • Copeland, R A
  • Dowling, R L
  • Jaffee, B D
  • Gardner, T L
  • Jones, E A
  • Magolda, R L
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Feb 03, 1998
Volume
8
Issue
3
Pages
307–312
Identifiers
PMID: 9871675
Source
Medline
License
Unknown

Abstract

The structure-activity relationships of some tetracyclic heterocycles related to Brequinar were explored. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction are related to ring system, heteroatom placement, and pendant ring substitution.

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