Affordable Access

Structure-activity relationship of trans-resveratrol and its analogues.

Authors
  • Ovesná, Z
  • Horváthová-Kozics, K
Type
Published Article
Journal
Neoplasma
Publication Date
Jan 01, 2005
Volume
52
Issue
6
Pages
450–455
Identifiers
PMID: 16284688
Source
Medline
License
Unknown

Abstract

Cancer is one of the main causes of death in both men and women, claiming over 6 million people each year worldwide. Chemoprevention in combination with anti-cancer treatment is therefore important to reduce morbidity and mortality. Stilbene-based compounds have over the years attracted attention of many researchers due to their wide ranging biological activities. One of the most relevant and extensively studied stilbenes is trans-resveratrol, a phytoalexin present in grapes and other foods. One of the most striking biological activities of trans-resveratrol soundly investigated during recent years has been its cancer-chemopreventive potential. It has been found that the biological activity of trans-resveratrol and its analogues depends significantly on the structural determinants, which are (i) number and position of hydroxyl groups, (ii) intramolecular hydrogen bonding, (iii) stereoisomery and (iv) double bond. The observation that trans-stilbene compounds having 4 -hydroxy group, double bond and bearing ortho-diphenoxyl or para-diphenoxyl functionalities possess remarkably higher chemopreventive activity than trans-resveratrol gives us useful information for further chemopreventive drug design.

Report this publication

Statistics

Seen <100 times