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Structure-activity delineation of quinones related to the biologically active Calothrixin B.

Authors
  • Bernardo, Paul H
  • Chai, Christina L L
  • Le Guen, Maurice
  • Smith, Geoffrey D
  • Waring, Paul
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 01, 2007
Volume
17
Issue
1
Pages
82–85
Identifiers
PMID: 17098429
Source
Medline
License
Unknown

Abstract

Quinones such as Calothrixins A and B display a range of biological properties. As part of our ongoing studies to elucidate the mechanism of action of the Calothrixins, several related quinones were synthesized and tested for biological activity. The results of the structure-activity relationship (SAR) studies are reported here.

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