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Structural insights into SARS-CoV-2 proteins.

Authors
  • Arya, Rimanshee1
  • Kumari, Shweta1
  • Pandey, Bharati1
  • Mistry, Hiral2
  • Bihani, Subhash C1
  • Das, Amit1
  • Prashar, Vishal1
  • Gupta, Gagan D2
  • Panicker, Lata1
  • Kumar, Mukesh3
  • 1 Protein Crystallography Section, Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India. , (India)
  • 2 Protein Crystallography Section, Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India. , (India)
  • 3 Protein Crystallography Section, Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India. Electronic address: [email protected] , (India)
Type
Published Article
Journal
Journal of Molecular Biology
Publisher
Elsevier
Publication Date
Nov 24, 2020
Volume
433
Issue
2
Pages
166725–166725
Identifiers
DOI: 10.1016/j.jmb.2020.11.024
PMID: 33245961
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The unprecedented scale of the ongoing COVID-19 pandemic has catalyzed an intense effort of the global scientific community to unravel different aspects of the disease in a short time. One of the crucial aspects of these developments is the determination of more than three hundred experimental structures of SARS-CoV-2 proteins in the last few months. These include structures of viral non-structural, structural, and accessory proteins and their complexes determined by either X-ray diffraction or cryo-electron microscopy. These structures elucidate the intricate working of different components of the viral machinery at the atomic level during different steps of the viral life cycle, including attachment to the host cell, viral genome replication and transcription, and genome packaging and assembly of the virion. Some of these proteins are also potential targets for drug development against the disease. In this review, we discuss important structural features of different SARS-CoV-2 proteins with their function, and their potential as a target for therapeutic interventions. Copyright © 2020 Elsevier Ltd. All rights reserved.

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