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[Structural and functional characteristics of the sarcoplasmic reticulum membranes of the skeletal muscles in thyrotoxicosis].

Authors
  • Tashmukhamedov, B A
  • Zamaraeva, M V
  • Gagel'gans, A I
  • Kliuev, S N
  • Salakhutdinov, B A
Type
Published Article
Journal
Voprosy medit︠s︡inskoĭ khimii
Publication Date
Jan 01, 1981
Volume
27
Issue
6
Pages
769–773
Identifiers
PMID: 6278759
Source
Medline
License
Unknown

Abstract

A rate of CA2+ accumulation and efficiency of Ca2+-pump were decreased in the fractions of skeletal muscle sarcoplasmic reticulum isolated from rabbits with thyrotoxicosis. Temperature of phase transition in membranes of sarcoplasmic reticulum was changed by 4-5 degrees towards low temperatures. Under conditions of thyrotoxicosis fatty acid composition of total lipids from the sarcoplasmic reticulum fractions was altered as follows: amount of palmitic acid was increased 1.4-fold but oleic and arachidonic acids were decreased 21.8% and 40.5%, respectively. Modification of Ca2+-transport properties in sarcoplasmic reticulum caused by long-term administration of thyroid hormones into animals appears to alter the membrane protein-lipid composition.

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