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Structural development of liver X receptor (LXR) antagonists derived from thalidomide-related glucosidase inhibitors.

Authors
Type
Published Article
Journal
Chemical & pharmaceutical bulletin
Publication Date
Volume
55
Issue
12
Pages
1750–1754
Identifiers
PMID: 18057753
Source
Medline
License
Unknown

Abstract

Following our previous discovery of LXR antagonistic activity of 2'-substituted phenylphthalimides derived from thalidomide-related glucosidase inhibitors, structure-activity studies and further structural development led to 5-chloro-N-2'-n-pentylphenyl-1,3-dithiophthalimide (5CPPSS-50), with IC50 values of about 10 and 13 microM for LXRalpha and LXRbeta, respectively.

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