Affordable Access

Structural development of liver X receptor (LXR) antagonists derived from thalidomide-related glucosidase inhibitors.

Authors
  • Noguchi-Yachide, Tomomi
  • Miyachi, Hiroyuki
  • Aoyama, Hiroshi
  • Aoyama, Atsushi
  • Makishima, Makoto
  • Hashimoto, Yuichi
Type
Published Article
Journal
Chemical & pharmaceutical bulletin
Publication Date
Dec 01, 2007
Volume
55
Issue
12
Pages
1750–1754
Identifiers
PMID: 18057753
Source
Medline
License
Unknown

Abstract

Following our previous discovery of LXR antagonistic activity of 2'-substituted phenylphthalimides derived from thalidomide-related glucosidase inhibitors, structure-activity studies and further structural development led to 5-chloro-N-2'-n-pentylphenyl-1,3-dithiophthalimide (5CPPSS-50), with IC50 values of about 10 and 13 microM for LXRalpha and LXRbeta, respectively.

Report this publication

Statistics

Seen <100 times