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Structural characterization of an acetylated glucomannan with antiinflammatory activity and gastroprotective property from Cyrtopodium andersonii.

Authors
  • Parente, José P1
  • Adão, Camila R2
  • da Silva, Bernadete P2
  • Tinoco, Luzineide W3
  • 1 Laboratório de Química de Plantas Medicinais, Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, PO Box 68045, CEP 21941-971 Rio de Janeiro, Brazil. Electronic address: [email protected] , (Brazil)
  • 2 Laboratório de Química de Plantas Medicinais, Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, PO Box 68045, CEP 21941-971 Rio de Janeiro, Brazil. , (Brazil)
  • 3 Laboratório Multiusuário de Análises por Ressonância Magnética Nuclear, Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, CEP 21941-902 Rio de Janeiro, Brazil. , (Brazil)
Type
Published Article
Journal
Carbohydrate research
Publication Date
Jun 04, 2014
Volume
391
Pages
16–21
Identifiers
DOI: 10.1016/j.carres.2014.03.021
PMID: 24751855
Source
Medline
Keywords
License
Unknown

Abstract

A polysaccharide with an estimated weight-average molar mass of 5.35×10(5) was obtained from an aqueous extract of pseudobulbs of Cyrtopodium andersonii R. Br. It was composed of d-glucose and d-mannose in 1:3 molar ratio. Chemical and spectroscopic analyses revealed a linear structure of the polymer with a backbone composed of (1→4)-linked β-d-glucopyranosyl and mannopyranosyl units slightly branched at C-2, C-3, and C-6 by side chains, as terminal non reducing residues of d-mannopyranose and d-glucopyranose. It was found to contain 14.6% of acetyl groups substituted at C-2 of (1→4)-linked β-d-mannopyranosyl units. The acetylated glucomannan demonstrated antiinflammatory and antiulcerogenic activities.

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