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Structural characteristics of mPEG-PDLLA and their effects on micelle stability

Authors
  • Min, Bumchan1
  • Seo, Minhyo1
  • Kim, Bong Oh1
  • Koh, Youngjoo1
  • Yi, Yilwoong1
  • Kim, Hyerim1
  • 1 Samyang Biopharmaceuticals Corp, Pangyo-ro 295, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, South Korea , Seongnam-si (South Korea)
Type
Published Article
Journal
Colloid & Polymer Science
Publisher
Springer-Verlag
Publication Date
Mar 27, 2019
Volume
297
Issue
5
Pages
785–793
Identifiers
DOI: 10.1007/s00396-019-04495-5
Source
Springer Nature
Keywords
License
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Abstract

The correlation between polymer microstructure of mPEG-PDLLA and secondary aggregation of its micelle was studied. Close examination of 1H NMR spectra revealed that the methine moieties, -CH(CH3)-, of mPEG-PDLLA polymer well represented its microstructure. To elucidate the physicochemical characteristics of various microstructures, we have developed an index, called L-ratio, to indicate the relative content of heterotactic component within the polymer. Storage stability of micelles from six polymers with different L-ratios (L-ratio ranging from 28 to 33%) was studied at 30 °C and 50 °C, and changes in average particle size were monitored to evaluate their secondary aggregation. We have found that polymers with high L-ratio takes longer time to secondary aggregation of polymeric micelles to occur. The findings should provide insightful guidance in the development of polymeric micelles.

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