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Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants

Authors
  • Jackson-Jones, Lucy Helen1, 2
  • Smith, Peter1
  • Portman, Jordan Raymond3
  • Magalhaes, Marlène Sophie1
  • Mylonas, Katie Jude1, 3
  • Vermeren, Matthieu Marie4
  • Nixon, Mark1
  • Henderson, Beth Emily Pollot3
  • Dobie, Ross3
  • Vermeren, Sonja3
  • Denby, Laura1
  • Henderson, Neil Cowan3, 5
  • Mole, Damian James3
  • Bénézech, Cécile1
  • 1 Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK
  • 2 Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK
  • 3 Centre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK
  • 4 Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4TJ, UK
  • 5 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Type
Published Article
Journal
Immunity
Publication Date
Apr 14, 2020
Volume
52
Issue
4
Pages
700–715
Identifiers
DOI: 10.1016/j.immuni.2020.03.011
PMID: 32294409
PMCID: PMC7156918
Source
PubMed Central
Keywords
License
Unknown

Abstract

For decades, the omentum has been known as the policeman of the abdomen. Jackson-Jones et al. reveal the existence of specialized mesothelial cells within fat-associated lymphoid clusters of the omentum that are responsible for the capture of peritoneal contaminants via the formation of neutrophil aggregates, preventing systemic spread.

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