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Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells

Authors
  • Cornelis, Rebecca1
  • Hahne, Stefanie1
  • Taddeo, Adriano1
  • Petkau, Georg1
  • Malko, Darya1
  • Durek, Pawel1
  • Thiem, Manja1
  • Heiberger, Lukas1
  • Peter, Lena1
  • Mohr, Elodie1
  • Klaeden, Cora1
  • Tokoyoda, Koji1
  • Siracusa, Francesco1
  • Hoyer, Bimba Franziska1, 2
  • Hiepe, Falk1, 2
  • Mashreghi, Mir-Farzin1
  • Melchers, Fritz1
  • Chang, Hyun-Dong1
  • Radbruch, Andreas1
  • 1 Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), a Leibniz Institute, Chariteplatz1, 10117 Berlin, Germany
  • 2 Charité-Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, 10117 Berlin, Germany
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Aug 04, 2020
Volume
32
Issue
5
Identifiers
DOI: 10.1016/j.celrep.2020.107982
PMID: 32755576
PMCID: PMC7408492
Source
PubMed Central
Keywords
License
Unknown

Abstract

In this study, Cornelis et al. address the molecular mechanisms underlying the survival of murine memory plasma cells in the bone marrow. The authors provide evidence that direct contact to stromal cells and exogenous APRIL provide resilience to mitochondrial and endoplasmic stress, respectively, synergistically promoting plasma cell survival.

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