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Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus.

Authors
Type
Published Article
Journal
Epilepsia
Publication Date
Volume
45
Issue
12
Pages
1488–1497
Identifiers
PMID: 15571506
Source
Medline

Abstract

These data demonstrate that, similar to patients with epilepsy, rats with SRSs markedly differ in their individual responses to AED treatment. Pharmacoresistant rats selected by prolonged drug treatment from groups of rats with SRSs may provide a unique model to study mechanisms of pharmacoresistance and to identify novel AEDs for treating seizures of patients currently not controlled with existing therapies.

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