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Strict blood-pressure control and progression of renal failure in children.

Authors
  • Wühl, Elke
  • Trivelli, Antonella
  • Picca, Stefano
  • Litwin, Mieczyslaw
  • Peco-Antic, Amira
  • Zurowska, Aleksandra
  • Testa, Sara
  • Jankauskiene, Augustina
  • Emre, Sevinc
  • Caldas-Afonso, Alberto
  • Anarat, Ali
  • Niaudet, Patrick
  • Mir, Sevgi
  • Bakkaloglu, Aysin
  • Enke, Barbara
  • Montini, Giovanni
  • Wingen, Ann-Margret
  • Sallay, Peter
  • Jeck, Nikola
  • And 16 more
Type
Published Article
Journal
New England Journal of Medicine
Publisher
New England Journal of Medicine
Publication Date
Oct 22, 2009
Volume
361
Issue
17
Pages
1639–1650
Identifiers
DOI: 10.1056/NEJMoa0902066
PMID: 19846849
Source
Medline
License
Unknown

Abstract

Intensified blood-pressure control, with target 24-hour blood-pressure levels in the low range of normal, confers a substantial benefit with respect to renal function among children with chronic kidney disease. Reappearance of proteinuria after initial successful pharmacologic blood-pressure control is common among children who are receiving long-term ACE inhibition. (ClinicalTrials.gov number, NCT00221845.)

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