Affordable Access

Access to the full text

The stress of starvation: glucocorticoid restraint of beta cell development

Authors
  • Matthews, L. C.1
  • Hanley, N. A.1
  • 1 Manchester Academic Health Sciences Centre, AV Hill Building, University of Manchester, Endocrinology and Diabetes Group, School of Biomedicine, Manchester, M13 9PT, UK , Manchester (United Kingdom)
Type
Published Article
Journal
Diabetologia
Publisher
Springer-Verlag
Publication Date
Nov 12, 2010
Volume
54
Issue
2
Pages
223–226
Identifiers
DOI: 10.1007/s00125-010-1963-x
Source
Springer Nature
Keywords
License
Green

Abstract

Developmental insults during gestation, such as under-nutrition, are known to restrict the number of beta cells that form in the fetal pancreas and are maintained in adulthood, leading to increased risk of type 2 diabetes. There are now substantial data indicating that glucocorticoids mediate this effect of under-nutrition on beta cell mass and that even at physiological levels they restrain fetal beta cell development in utero. There are emerging clues that this occurs downstream of endocrine commitment by neurogenin 3 but prior to terminal beta cell differentiation. Deciphering the precise mechanism will be important as it might unveil new pathways by which to manipulate beta cell mass that could be exploited as novel therapies for patients with diabetes.

Report this publication

Statistics

Seen <100 times