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Stress-induced expression of transcriptional repressor ICER in the adrenal gland.

Authors
  • Della Fazia, M A
  • Servillo, G
  • Foulkes, N S
  • Sassone-Corsi, P
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Aug 28, 1998
Volume
434
Issue
1-2
Pages
33–36
Identifiers
PMID: 9738446
Source
Medline
License
Unknown

Abstract

Second messenger cyclic AMP plays a central role in signalling within the hypothalamo-pituitary-adrenal (HPA) axis. Changes in gene expression are central to long-term adaptations made in response to stress in the adrenal gland. Here we demonstrate that expression of the cAMP inducible transcriptional repressor, ICER (Inducible cAMP Early Repressor), is rapidly and powerfully induced in response to surgical stress in the rat adrenal gland. Hypophysectomisation blocks stress-induced ICER expression. Finally we demonstrate that injection of the pituitary hormone ACTH (Adrenocorticotropin Hormone) induces robust ICER expression in the adrenal cortex. Thus, induction of the transcriptional repressor ICER is coupled to the HPA axis response to stress.

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