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Stress-induced changes in LPS-induced pro-inflammatory cytokine production in chronic fatigue syndrome.

Authors
  • Gaab, Jens
  • Rohleder, Nicolas
  • Heitz, Vera
  • Engert, Veronika
  • Schad, Tanja
  • Schürmeyer, Thomas H
  • Ehlert, Ulrike
Type
Published Article
Journal
Psychoneuroendocrinology
Publisher
Elsevier
Publication Date
Feb 01, 2005
Volume
30
Issue
2
Pages
188–198
Identifiers
PMID: 15471616
Source
Medline
License
Unknown

Abstract

CFS patients do not show an exaggerated secretion of LPS-induced cytokines. Although cortisol responses to stress were normal, pro-inflammatory cytokine levels in CFS patients were significantly attenuated. Possible intracellular mechanisms, such as for example an enhanced sensitivity to inhibitory effects of glucocorticoids, a diminished responsivity to catecholaminergic stimulation, and a disruption of intracellular activation are discussed. Basal levels of stimulated pro-inflammatory Il-6 levels are generally related to fatigue scores. However, in CFS patients this association is of greater magnitude and can also be observed for TNF-alpha.

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