Affordable Access

Publisher Website

Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory.

Authors
Type
Published Article
Journal
Nature reviews. Neuroscience
1471-003X
Publication Date
Volume
11
Issue
10
Pages
675–681
Identifiers
DOI: 10.1038/nrn2913
PMID: 20820185
Source
Medline

Abstract

The acquisition and consolidation of memories of stressful events is modulated by glucocorticoids, a type of corticosteroid hormone that is released in high levels from the adrenal glands after exposure to a stressful event. These effects occur through activation of mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs). The molecular mechanisms that underlie the effects of glucocorticoids on synaptic transmission, synaptic plasticity, learning and memory have recently begun to be identified. Glucocorticoids regulate AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate) receptor trafficking--which is crucially involved in synaptic transmission and plasticity--both rapidly and persistently. Stress hormones may, through modulation of AMPA receptor function, promote the consolidation of behaviourally relevant information.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments