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Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines.

Authors
  • Lynch, Joseph P 3rd
  • Zhanel, George G
Type
Published Article
Journal
Current opinion in pulmonary medicine
Publication Date
May 01, 2010
Volume
16
Issue
3
Pages
217–225
Identifiers
DOI: 10.1097/MCP.0b013e3283385653
PMID: 20375783
Source
Medline
License
Unknown

Abstract

Following usage of the pneumococcal conjugate vaccine in children, the incidence of invasive pneumococcal disease declined in both children and adults (reflecting herd immunity). However, emergence of serotypes not encompassed in the vaccine is worrisome, and may be associated with heightened antimicrobial resistance and virulence. Continued vigilance for emergence of novel serotypes and development of vaccines with expanded coverage and immunogenicity will be critical for optimal prevention of pneumococcal infections.

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