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Strength and Endurance Training in Older Women in Relation to ACTN3 R577X and ACE I/D Polymorphisms

Authors
  • Romero-Blanco, Cristina
  • Artiga-González, María Jesús
  • Gómez-Cabello, Alba1
  • Vila-Maldonado, Sara2, 3
  • Casajús, José Antonio1
  • Ara, Ignacio2, 3
  • Aznar, Susana3
  • 1 (J.A.C.)
  • 2 (I.A.)
  • 3 CIBERFES Biomedical Research Networking Center on Frailty and Health Aging, 28029 Madrid, Spain
Type
Published Article
Journal
International Journal of Environmental Research and Public Health
Publisher
MDPI AG
Publication Date
Feb 14, 2020
Volume
17
Issue
4
Identifiers
DOI: 10.3390/ijerph17041236
PMID: 32075076
PMCID: PMC7068405
Source
PubMed Central
Keywords
License
Green

Abstract

The purpose of this study is to analyze the effect of two genetic polymorphisms, ACTN3 R577X , and ACE I/D , on physical condition in a sample of active older women after a two-year training period. The sample was composed of 300 healthy women over the age of 60 who underwent a two-year training program. Adapted tests from the Senior Fitness Test were used. The genotyping of the polymorphisms was obtained from the participants’ DNA via buccal swabs. The analysis of the ACE polymorphism did not reveal differences between genotypes. The analysis of the R577X polymorphism showed a favorable effect for the ACTN3 XX genotype in tests for leg strength ( p : 0.001) after training, compared to the other genotypes, and also in the analysis of the combined effect of the polymorphism ( ACE II + ACTN3 RX/XX ). The intragroup effect revealed an improvement in arm strength for carriers of the X allele after 24 months of training ( p < 0.05). The endurance values significantly worsened in all study groups. Conclusions: The R577X polymorphism of ACTN3 may have an important role in capacities related to muscle strength, providing a beneficial effect for carriers of the X allele.

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