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Stratification of rodent carcinogenicity bioassay results to reflect relative human hazard.

Authors
  • Tennant, R W
Type
Published Article
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Publisher
Elsevier
Publication Date
Mar 01, 1993
Volume
286
Issue
1
Pages
111–118
Identifiers
PMID: 7678907
Source
Medline
License
Unknown

Abstract

Trans-species, multiple site (particularly common site between species), mutagenic rodent carcinogens are less affected by the influences of polymorphic genes than are chemicals inducing more limited carcinogenic effects. Trans-species carcinogens, therefore, should represent a first priority for attention for human health risk.

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