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Strategies in the Design and Use of Synthetic "Internal Glycan" Vaccines.

Authors
  • Lakshminarayanan, Abirami1
  • Vijayakrishnan, Balakumar1
  • Bayley, Hagan1
  • Davis, Benjamin G2
  • 1 University of Oxford, Oxford, United Kingdom. , (United Kingdom)
  • 2 University of Oxford, Oxford, United Kingdom. Electronic address: [email protected] , (United Kingdom)
Type
Published Article
Journal
Methods in enzymology
Publication Date
Jan 01, 2017
Volume
597
Pages
335–357
Identifiers
DOI: 10.1016/bs.mie.2017.06.008
PMID: 28935110
Source
Medline
Keywords
License
Unknown

Abstract

The relative structural conservation of "internal glycans" in the cell walls of pathogens suggests that they might as target epitopes less prone to variation and hence with greater potential universality as vaccine targets. Examples of such glycans include the inner core sugars of lipopolysaccharides in Gram-negative bacteria. However, due to the buried nature of such internal epitopes, this approach has been rarely adopted. Here we briefly review and compare strategic approaches and outline practical methods associated with evaluating one synergistic strategy that combines (i) blocking of the display of "external glycans" with (ii) vaccination targeted at "internal glycans."

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