Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Strain-related effects of fenbendazole treatment on murine experimental autoimmune encephalomyelitis.

Authors
  • Ramp, A A
  • Hall, C
  • Orian, J M
Type
Published Article
Journal
Laboratory Animals
Publisher
SAGE Publications
Publication Date
Jul 01, 2010
Volume
44
Issue
3
Pages
271–273
Identifiers
DOI: 10.1258/la.2010.009148
PMID: 20457828
Source
Medline
License
Unknown

Abstract

Parasitic infections are a concern in animal facilities, in view of their influence on physiological processes and the immune status of animals. Pinworms are effectively controlled with the anthelminthic fenbendazole (FBZ, [5-(phenylthio)-1H-benzamidazol-2-yl]carbamic acid methyl ester; C(15)H(13)N(3)O(2)S); however, questions remain as to whether prolonged FBZ exposure alters the disease course in specific experimental models, such as those pertaining to the immune system. We report that a three-month regimen of FBZ-medicated feed severely affected the onset and disease severity of murine experimental autoimmune encephalomyelitis (EAE), a disease that mimics multiple sclerosis. Differences were recorded between mouse strains used. Our data suggest that where the use of FBZ is mandatory, its full effect should be verified on the particular EAE variant adopted by the laboratory.

Report this publication

Statistics

Seen <100 times