STORI Plots Enable Accurate Tracking of Individual Ion Signals.
Departments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, The Proteomics Center of Excellence at Northwestern University, Evanston, IL, 60208, USA.
S.C. Beu Consulting, Austin, TX, 78729, USA.
Thermo Fisher Scientific, San Jose, CA, 95134, USA.
Thermo Fisher Scientific, 28199, Bremen, Germany.
Thermo Fisher Scientific, Austin, TX, 78728, USA.
Thermo Fisher Scientific, San Jose, CA, 95134, USA. [email protected]
- Published Article
Journal of the American Society for Mass Spectrometry
- Publication Date
Nov 01, 2019
Charge detection mass spectrometry (CDMS) of low-level signals is currently limited to the analysis of individual ions that generate a persistent signal during the entire observation period. Ions that disintegrate during the observation period produce reduced frequency domain signal amplitudes, which lead to an underestimation of the ion charge state, and thus the ion mass. The charge assignment can only be corrected through an accurate determination of the time of ion disintegration. The traditional mechanisms for temporal signal analysis have severe limitations for temporal resolution, spectral resolution, and signal-to-noise ratios. Selective Temporal Overview of Resonant Ions (STORI) plots provide a new framework to accurately analyze low-level time domain signals of individual ions. STORI plots allow for complete correction of intermittent signals, the differentiation of single and multiple ions at the same frequency, and the association of signals that spontaneously change frequency.
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This record was last updated on 11/21/2019 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/31512223