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Stool microbiota and vaccine responses of infants.

Authors
  • Huda, M Nazmul
  • Lewis, Zachery
  • Kalanetra, Karen M
  • Rashid, Mamunur
  • Ahmad, Shaikh M
  • Raqib, Rubhana
  • Qadri, Firdausi
  • Underwood, Mark A
  • Mills, David A
  • Stephensen, Charles B
Type
Published Article
Journal
PEDIATRICS
Publisher
American Academy of Pediatrics
Publication Date
Aug 01, 2014
Volume
134
Issue
2
Identifiers
DOI: 10.1542/peds.2013-3937
PMID: 25002669
Source
Medline
Keywords
License
Unknown

Abstract

Bifidobacterium predominance may enhance thymic development and responses to both oral and parenteral vaccines early in infancy, whereas deviation from this pattern, resulting in greater bacterial diversity, may cause systemic inflammation (neutrophilia) and lower vaccine responses. Vaccine responsiveness may be improved by promoting intestinal bifidobacteria and minimizing dysbiosis early in infancy.

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