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Stochastic microswimming model for the average translational velocity of the ribosome.

Authors
  • González-García, José S
  • Delgado, Joaquín
Type
Published Article
Journal
Physical Review E
Publisher
American Physical Society (APS)
Publication Date
Jul 01, 2013
Volume
88
Issue
1
Pages
12723–12723
Identifiers
PMID: 23944506
Source
Medline
License
Unknown

Abstract

The motion of the ribosome is modeled here, assuming that its two subunits are subject to stochastic rearrangements, thus producing different conformations constituting its deformation cycle, or swimming stroke. Using a general statistical mechanical formulation, the mean propulsion velocity of the ribosome is obtained as a function of the transition rates among the different conformations and of the relevant deformation variables. A calculation with reasonable parameter estimations shows that the ribosome can match the average protein synthesis speed with deformations of a size comparable to its radius.

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