Affordable Access

deepdyve-link
Publisher Website

Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers.

Authors
Type
Published Article
Journal
Advanced Drug Delivery Reviews
Publisher
Elsevier
Volume
66
Pages
58–73
Identifiers
DOI: 10.1016/j.addr.2013.09.008
Source
Kit Lam Lab
License
Unknown

Abstract

Stimuli-responsive cross-linked micelles (SCMs) represent an ideal nanocarrier system for drug delivery against cancers. SCMs exhibit superior structural stability compared to their non-cross-linked counterpart. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive cross-linkers or assembly units makes SCMs responsive to single or multiple stimuli present in tumor local microenvironment or exogenously applied stimuli. In these instances, the payload drug is released almost exclusively in cancerous tissue or cancer cells upon accumulation via enhanced permeability and retention effect or receptor mediated endocytosis. In this review, we highlight recent advances in the development of SCMs for cancer therapy. We also introduce the latest biophysical techniques, such as electron paramagnetic resonance (EPR) spectroscopy and fluorescence resonance energy transfer (FRET), for the characterization of the interactions between SCMs and blood proteins.

Report this publication

Statistics

Seen <100 times