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Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones.

Authors
  • Hamilton, J A
  • Lingelbach, S R
  • Partridge, N C
  • Martin, T J
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Jul 18, 1984
Volume
122
Issue
1
Pages
230–236
Identifiers
PMID: 6611156
Source
Medline
License
Unknown

Abstract

Hormonal control of plasminogen activator (PA) was studied in clonal rat osteogenic sarcoma cells which are phenotypically osteoblast, and in osteoblast-rich rat bone cell cultures. The bone-resorbing hormones (parathyroid hormone, prostaglandin E2, epidermal growth factor and 1,25-dihydroxyvitamin D3) stimulated PA activity in both cell types. The relative efficacies of vitamin D metabolites and of prostanoids reflect their relative potencies as stimulators of bone resorption.

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