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Stimulation of cGMP signalling protects coronary endothelium against reperfusion-induced intercellular gap formation.

Authors
  • Kasseckert, Sascha A
  • Schäfer, Claudia
  • Kluger, Angelika
  • Gligorievski, Dragan
  • Tillmann, Julia
  • Schlüter, Klaus-Dieter
  • Noll, Thomas
  • Sauer, Heinrich
  • Piper, Hans Michael
  • Abdallah, Yaser
Type
Published Article
Journal
Cardiovascular Research
Publisher
Oxford University Press
Publication Date
Jul 15, 2009
Volume
83
Issue
2
Pages
381–387
Identifiers
DOI: 10.1093/cvr/cvp065
PMID: 19234300
Source
Medline
License
Unknown

Abstract

sGC/PKG activation during reperfusion reduces reperfusion-induced endothelial intercellular gap formation by attenuation of cytosolic calcium overload and reduction of contractile activation in endothelial cells. This mechanism protects the heart against reperfusion-induced oedema.

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