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Stimulated CB1 Cannabinoid Receptor Inducing Ischemic Tolerance and Protecting Neuron from Cerebral Ischemia.

Authors
  • Zhuang, Quankun1
  • Dai, Cailing1
  • Yang, Linglong1
  • Wen, Huimin1
  • Wang, Hongyun1
  • Jiang, Xiaoxue1
  • Zhang, Yuyang2
  • 1 Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China. , (China)
  • 2 Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China. , (China)
Type
Published Article
Journal
Central nervous system agents in medicinal chemistry
Publication Date
Jan 01, 2017
Volume
17
Issue
2
Pages
141–150
Identifiers
DOI: 10.2174/1871524916666160504104624
PMID: 27142423
Source
Medline
Keywords
License
Unknown

Abstract

CB1R played an important part via several signaling pathways in the protection from ischemic stroke and in ischemic tolerance. The involved molecular signaling pathways include ERK1/2, PI3K/Akt/GSK-3β and the translocation and activation of PKCε. With the intimate association between CB1R and neuron injuries, to target the receptor will exert neuroprotective effects on cerebral ischemia, which provides wide foreground for a novel therapy target.

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