Affordable Access

deepdyve-link
Publisher Website

Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cells.

Authors
  • Keimpema, Erik
  • Straiker, Alex
  • Mackie, Ken
  • Harkany, Tibor
  • Hjerling-Leffler, Jens
Type
Published Article
Journal
The Journal of Physiology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Feb 15, 2012
Volume
590
Issue
Pt 4
Pages
703–714
Identifiers
DOI: 10.1113/jphysiol.2011.224386
PMID: 22219340
Source
Medline
License
Unknown

Abstract

Certain essential cognitive processes require the precise temporal interplay between glutamatergic (excitatory) pyramidal cells and γ-aminobutyric acid (GABA)-releasing inhibitory interneurons in the hippocampus. Basket cells, the main class of interneurons, target pyramidal cell somata and proximal dendrites and thus are poised to modify network oscillations. Though only present in limited numbers, the impaired development of basket cells can result in changes in the hippocampal circuitry leading to neurological disorders, such as schizophrenia. The diversity of the spatial origins, neurochemical make-up, cytoarchitecture and network contributions amongst basket cells is a provocative example of interneuron heterogeneity in the hippocampus. This review discusses recent data concerned with the developmental trajectories of one subclass, the cholecystokinin-containing basket cell, and emphasizes the significance of the short-range intercellular guidance cues that have recently emerged to impact the formation and function of their inhibitory synapses.

Report this publication

Statistics

Seen <100 times