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Sterols and Triterpenes: Antiviral     Potential Supported by In-Silico Analysis

Authors
  • Hisham Shady, Nourhan
  • Youssif, Khayrya A.
  • Sayed, Ahmed M.1
  • Belbahri, Lassaad
  • Oszako, Tomasz
  • Hassan, Hossam M.1, 2
  • Abdelmohsen, Usama Ramadan3
  • 1 (H.M.H.)
  • 2 Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt
  • 3 Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
Type
Published Article
Journal
Plants
Publisher
MDPI AG
Publication Date
Dec 26, 2020
Volume
10
Issue
1
Identifiers
DOI: 10.3390/plants10010041
PMID: 33375282
PMCID: PMC7823815
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Green

Abstract

The acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) caused severe panic all over the world. The coronavirus (COVID-19) outbreak has already brought massive human suffering and major economic disruption and unfortunately, there is no specific treatment for COVID-19 so far. Herbal medicines and purified natural products can provide a rich resource for novel antiviral drugs. Therefore, in this review, we focused on the sterols and triterpenes as potential candidates derived from natural sources with well-reported in vitro efficacy against numerous types of viruses. Moreover, we compiled from these reviewed compounds a library of 162 sterols and triterpenes that was subjected to a computer-aided virtual screening against the active sites of the recently reported SARS-CoV-2 protein targets. Interestingly, the results suggested some compounds as potential drug candidates for the development of anti-SARS-CoV-2 therapeutics.

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