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Are Steroid Hormones Dysregulated in Autistic Girls?

Authors
  • Gasser, Benedikt Andreas
  • Kurz, Johann1
  • Dick, Bernhard
  • Mohaupt, Markus Georg1
  • 1 (M.G.M.)
Type
Published Article
Journal
Diseases
Publisher
MDPI
Publication Date
Mar 14, 2020
Volume
8
Issue
1
Identifiers
DOI: 10.3390/diseases8010006
PMID: 32183287
PMCID: PMC7151154
Source
PubMed Central
Keywords
License
Green

Abstract

Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas chromatography mass spectrometry-based steroid hormone metabolite analysis was conducted from autistic girls. Results show increased levels of several steroid hormones, especially in the class of androgens in autistic girls such as testosterone or androstenediol. The increase of the majority of steroid hormones in autistic girls is probably best explained multifactorially by a higher substrate provision in line with the previously developed cholesterol hypothesis of autism.

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