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Stereoselectivity in the human metabolism of methamphetamine.

Authors
Type
Published Article
Journal
British Journal of Clinical Pharmacology
1365-2125
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
69
Issue
2
Pages
187–192
Identifiers
DOI: 10.1111/j.1365-2125.2009.03576.x
PMID: 20233182
Source
Medline
License
Unknown

Abstract

The metabolism of MA is enantioselective, with formation of AMP having the highest isomer selectivity. A greater percentage of MA is converted to pOH-MA (8-11%) than AMP (2-7%). The formation of pOH-MA was less affected by the MA enantiomer administered, suggesting that urine pOH-MA may be a more stable biomarker of MA metabolism.

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