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Stereoselective synthesis of thiazino[4,3-a]indoles using the thia-Pictet-Spengler reaction of indoles bearing N-tethered thiols and vinylogous thiocarbonates

Authors
  • GHARPURE, SJ
  • NANDA, SK
Publication Date
Jan 01, 2016
Source
DSpace at IIT Bombay
Keywords
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Unknown
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Abstract

An inter-as well as intra-molecular thia-Pictet-Spengler cyclization of N-tethered thiols and vinylogous thiocarbonates is described for the stereoselective synthesis of N-fused thiazinoindole derivatives. The strategy is extended to one-pot, sequential Friedel-Crafts alkylation -Pictet-Spengler cyclization and the synthesis of thiazino-oxepino-indole.

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