Stereochemistry of the reduction of 24-ethyldesmosterol to sitosterol in tissue cultures of Oryza sativa.
- Authors
- Type
- Published Article
- Journal
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier
- Publication Date
- Feb 03, 1998
- Volume
- 8
- Issue
- 3
- Pages
- 205–208
- Identifiers
- PMID: 9871655
- Source
- Medline
- License
- Unknown
Abstract
Feeding of [26-13C]- and [27-13C]-24-ethyldesmosterols to cultured cells of Oryza sativa followed by 13C-NMR analysis of the biosynthesized sitosterol revealed that the reduction of 24(25)-double bond proceeds with an anti-addition of hydrogen atoms, thus the E-methyl group of the olefinic precursor becomes the pro-S-methyl on C-25 of sitosterol.
