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Stereo-specific synthesis of (13r)-manoyl oxide

Authors
  • Hamberger, Björn
  • Pateraki, Eirini
  • Møller, Birger Lindberg
  • Nørholm, Morten
  • Nielsen, Morten Thrane
  • Ranberg, Johan Andersen
  • Bohlman, Carl Jorg
  • Zerbe, Philip
Publication Date
Jun 25, 2015
Source
Online Research Database In Technology
License
Unknown
External links

Abstract

<p>The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.</p>

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