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Stem cells improve right ventricular functional recovery after acute pressure overload and ischemia reperfusion injury.

Authors
  • Wairiuko, George M
  • Crisostomo, Paul R
  • Wang, Meijing
  • Morrell, Eric D
  • Meldrum, Kirstan K
  • Lillemoe, Keith D
  • Meldrum, Daniel R
Type
Published Article
Journal
The Journal of surgical research
Publication Date
Aug 01, 2007
Volume
141
Issue
2
Pages
241–246
Identifiers
PMID: 17583739
Source
Medline
License
Unknown

Abstract

This compounded injury model allowed the study of right ventricular dysfunction in the setting of acute pressure overload and ischemia. Additionally, we have also demonstrated that pretreatment with stem cells of an acutely pressure overloaded right ventricle prior to ischemia reperfusion injury improves functional recovery. This is the first report of a modified Langendorff technique to study right ventricular function in the setting of acute pressure overload and ischemia and the effect of pretreatment with stem cells.

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