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Stem Cells in Dermatology and Anti-aging Care of the Skin.

Authors
  • Taub, Amy Forman1
  • Pham, Kim2
  • 1 Department of Dermatology, Northwestern University, Medical School, Chicago, IL, USA; Advanced Dermatology, 275 Parkway Drive, Suite 521, Lincolnshire, IL 60069, USA; Advanced Dermatology, Glencoe, IL, USA. Electronic address: [email protected]
  • 2 University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA.
Type
Published Article
Journal
Facial plastic surgery clinics of North America
Publication Date
Nov 01, 2018
Volume
26
Issue
4
Pages
425–437
Identifiers
DOI: 10.1016/j.fsc.2018.06.004
PMID: 30213424
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Multipotent stem cells have paved the way for new applications and deeper understanding in regenerative medicine and the pathophysiology of aging. During skin aging, cumulative photodamage, exhaustion of endogenous stem cell populations, mechanical stress, and increased fibrosis lead to skin with decreased epidermal thickness and compromised dermal integrity. Specific stem cells in the hair follicle create new keratinocytes after activation by defensin peptides, released by neutrophils during wounding. Studies pertaining to defensin peptides' efficacy on skin aging have been published, highlighting their potential as a new therapy for skin rejuvenation. Copyright © 2018 Elsevier Inc. All rights reserved.

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