Affordable Access

deepdyve-link
Publisher Website

Long Non-coding RNA T-UCstem1 Controls Progenitor Proliferation and Neurogenesis in the Postnatal Mouse Olfactory Bulb through Interaction with miR-9

Authors
  • Pascale, Emilia1, 2
  • Beclin, Christophe3
  • Fiorenzano, Alessandro4
  • Andolfi, Gennaro1, 2
  • Erni, Andrea3
  • De Falco, Sandro2
  • Minchiotti, Gabriella1, 2
  • Cremer, Harold3
  • Fico, Annalisa1, 2
  • 1 Stem Cell Fate Laboratory, Institute of Genetics and Biophysics “A. Buzzati-Traverso”, CNR, 80131 Naples, Italy
  • 2 Institute of Genetics and Biophysics “A. Buzzati-Traverso”, CNR, 80131 Naples, Italy
  • 3 Aix-Marseille Université, CNRS, IBDM, 13288 Marseille, France
  • 4 Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden
Type
Published Article
Journal
Stem Cell Reports
Publisher
Elsevier
Publication Date
Sep 24, 2020
Volume
15
Issue
4
Pages
836–844
Identifiers
DOI: 10.1016/j.stemcr.2020.08.009
PMID: 32976763
PMCID: PMC7562942
Source
PubMed Central
Keywords
License
Unknown

Abstract

In this study, Fico, Beclin, and colleagues show that the long non-coding RNA T-UCstem1 is expressed in the forebrain neurogenic lineage generating interneurons for the postnatal olfactory bulb. Increased T-UCstem1 levels in neural stem cells induced progenitor proliferation at the expense of neuron production, whereas its downregulation caused the opposite effect. This regulatory function is mediated by its interaction with miR-9.

Report this publication

Statistics

Seen <100 times