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Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.

Authors
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
1524-4636
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Volume
32
Issue
7
Pages
1687–1695
Identifiers
DOI: 10.1161/ATVBAHA.112.250142
PMID: 22556332
Source
Medline
License
Unknown

Abstract

Intracellular accumulation of stearic acid in MPMs activates inflammatory signaling, leading to ER stress-mediated apoptosis. M1 macrophages are more prone to stearic acid-induced inflammation and ER stress. These same pathways may be activated in macrophages residing in atherosclerotic plaques and metabolic tissues during conditions of obesity and hyperlipidemia.

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