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STEALTH liposome-encapsulated cisplatin (SPI-77) versus carboplatin as adjuvant therapy for spontaneously arising osteosarcoma (OSA) in the dog: a randomized multicenter clinical trial.

Authors
  • Vail, David M
  • Kurzman, Ilene D
  • Glawe, Phyllis C
  • O'Brien, Maura G
  • Chun, Ruthanne
  • Garrett, Laura D
  • Obradovich, Joyce E
  • Fred, Rogers M 3rd
  • Khanna, Chand
  • Colbern, Gail T
  • Working, Peter K
Type
Published Article
Journal
Cancer chemotherapy and pharmacology
Publication Date
Aug 01, 2002
Volume
50
Issue
2
Pages
131–136
Identifiers
PMID: 12172978
Source
Medline
License
Unknown

Abstract

While STEALTH liposome encapsulation of cisplatin allowed the safe administration of five times the maximally tolerated dose of free cisplatin to dogs without concurrent hydration protocols, this did not translate into significantly prolonged DFS or OS. However, a larger proportion of dogs receiving SPI-77 enjoyed long-term DFS when compared with dogs receiving carboplatin.

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