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Steady-state sVCAM-1 serum levels in adults with sickle cell disease.

Authors
  • Schnog, J B1, 2, 3
  • Rojer, R A4
  • Mac Gillavry, M R5
  • Ten Cate, H5
  • Brandjes, D P M5
  • Duits, A J6
  • 1 Department of Internal Medicine, St. Elisabeth Hospital, Curaçao, Netherlands Antilles. [email protected] , ()
  • 2 Red Cross Bloodbank Curaçao, St. Elisabeth Hospital, Curaçao, Netherlands Antilles. [email protected] , ()
  • 3 Department of Internal Medicine (9B), Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. [email protected] , (Netherlands)
  • 4 Department of Internal Medicine, St. Elisabeth Hospital, Curaçao, Netherlands Antilles. , ()
  • 5 Department of Internal Medicine (9B), Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. , (Netherlands)
  • 6 Red Cross Bloodbank Curaçao, St. Elisabeth Hospital, Curaçao, Netherlands Antilles. , ()
Type
Published Article
Journal
Annals of hematology
Publication Date
Feb 01, 2003
Volume
82
Issue
2
Pages
109–113
Identifiers
DOI: 10.1007/s00277-003-0609-1
PMID: 12601490
Source
Medline
License
Unknown

Abstract

Cytokines and adhesion molecules play an important role in the pathophysiology of vaso-occlusion in sickle cell disease (SCD), and their in vivo profiles are potential tools for assessing SCD severity. We compared steady-state soluble vascular cell adhesion molecule-1 (sVCAM-1) serum levels to clinical (painful crisis frequency, occurrence of acute chest syndrome, leg ulcers, and cerebrovascular disease) and related hematological parameters of SCD severity (such as HbF%, hemoglobin levels, and leukocyte counts) in 29 HbSS adults. Serum sVCAM-1 levels were not related to clinical severity, but an inverse correlation was demonstrated between sVCAM-1 and hemoglobin levels (r=-0.71, p<0.001) with a positive correlation to serum lactate dehydrogenase levels (r=0.59, p=0.008). Based upon these results, steady-state serum sVCAM-1 levels do not seem to reflect clinical disease severity. However, as VCAM-1 is involved in hematopoiesis, sVCAM-1 levels might reflect bone marrow activity in SCD. This underlies the pleiotropic nature of adhesion molecules in vivo and the need for further research in this area, especially since therapies targeting (cellular) adhesive interactions involving the endothelium are emerging for SCD.

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