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Statolon-induced Resistance of Mice to Mengovirus

Authors
  • Jerome P. Schmidt
  • Frank F. Pindak
Publication Date
May 01, 1967
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

Mice receiving statolon intraperitoneally were 1,000 times more resistant to intraperitoneal challenge with mengovirus than were untreated controls. Protection was afforded when statolon was administered 1 day before or 1 day after intraperitoneal inoculation with the virus. No therapeutic effect was observed when treatment with statolon was delayed for 2 days or more after virus infection. Exposure of mice to a simulated space cabin environment did not increase their susceptibility to the lethal effects of mengovirus infection or eliminate the protective effect of statolon.

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