Affordable Access

deepdyve-link
Publisher Website

Statistical limitations in ion imaging.

Authors
  • Collins-Fekete, Charles-Antoine1, 2
  • Dikaios, Nikolaos3
  • Bär, Esther1
  • Evans, Philip M2, 3
  • 1 Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, United Kingdom. , (United Kingdom)
  • 2 Chemical, Medical and Environmental Science, National Physical Laboratory, Hampton Road, Teddington, United Kingdom. , (United Kingdom)
  • 3 Centre for Vision Speech and Signal Processing, University of Surrey, Guildford, United Kingdom. , (United Kingdom)
Type
Published Article
Journal
Physics in Medicine and Biology
Publisher
IOP Publishing
Publication Date
May 10, 2021
Volume
66
Issue
10
Identifiers
DOI: 10.1088/1361-6560/abee57
PMID: 33711829
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In this study, we investigated the capacity of various ion beams available for radiotherapy to produce high quality relative stopping power map acquired from energy-loss measurements. The image quality metrics chosen to compare the different ions were signal-to-noise ratio (SNR) as a function of dose and spatial resolution. Geant4 Monte Carlo simulations were performed for: hydrogen, helium, lithium, boron and carbon ion beams crossing a 20 cm diameter water phantom to determine SNR and spatial resolution. It has been found that protons possess a significantly larger SNR when compared with other ions at a fixed range (up to 36% higher than helium) due to the proton nuclear stability and low dose per primary. However, it also yields the lowest spatial resolution against all other ions, with a resolution lowered by a factor 4 compared to that of carbon imaging, for a beam with the same initial range. When comparing for a fixed spatial resolution of 10 lp cm-1, carbon ions produce the highest image quality metrics with proton ions producing the lowest. In conclusion, it has been found that no ion can maximize all image quality metrics simultaneously and that a choice must be made between spatial resolution, SNR, and dose. Creative Commons Attribution license.

Report this publication

Statistics

Seen <100 times